How to Win at Scrabble
Posted December 31st, 2002 @ 02:18pm by Erik J. Barzeski
Gotta keep this in mind for the next time I play... (source)
According to Craig Rowland, Scrabble in North America recognizes five words which, if spelled over two triple-word score squares, and with a premium-scoring tile on the double-letter score square, will award the player 392 points on a single play. These five words are: OXAZEPAM, BEZIQUES, CAZIQUES, MEZQUITS, and MEZQUITE.
John Chew says that OXYPHENBUTAZONE is the highest-scoring word known under American tournament Scrabble rules (OSPD+MWCD). It can score 1778 under suitably contrived circumstances listed and credited in the Scrabble FAQ.